HELLO! I'M Sanna.
Sanna Sillankorva is a Research Fellow at INL funded by a Marie-Curie COFUND. She works in the Department of Life Science within the Nano4Health group.
Sanna Sillankorva is a Research Fellow at INL funded by a Marie-Curie COFUND. She works in the Department of Life Science within the Nano4Health group. She holds a PhD degree in Chemical and Biological Engineering from the University of Minho, Portugal, that included visiting periods at the Universities of Oulu and Helsinki, Finland. Her PhD focused on the use of bacteriophages to control bacterial biofilms. After, Sanna was postdoctoral researcher (2009-2013) at the Centre of Biological Engineering of the University of Minho, spending, in 2013, a visiting period at the Synthetic Biology Lab of MIT working under the supervision of Dr. Timothy Lu. She became recipient of a 2013 FCT Investigator grant (2013-2018) that focused on the prevention and control of food and clinically relevant pathogens. She has coordinated 3 national projects, edited 2 hard-cover books and 1 eBook, published 48 articles and 8 book chapters, and supervised over 25 postdoctoral, PhD and MSc researchers.
The Cofund project
The project Sanna Sillankorva is carrying out relies on the development of a novel topical bacteriophage delivery system aiming their use for topical chronic wound management. The bacterial species targeted by the bacteriophages is Pseudomonas aeruginosa, a critical priority pathogen that, according to the World Health Organization, demands an R&D response due to its growing global resistance to antimicrobial medicines. Bacteriophages are viruses which infect a host organism (bacteria or archaea) and only multiply in the presence of their host. Bacteriophages can actively destroy biofilms and / or induce the host organism to do so. Multiplying within the host, they will induce host lysis and release progeny virion particles that will further infect other organisms of the same species.The fundamental concept behind the project is to combine bacteriophage, biofilm and ex vivo modelling expertise with the expertise in encapsulation techniques to produce targeted antibacterial polymeric microneedles that will be able to biodegrade once applied and be able to deliver a cocktail of bacteriophages to the site of infection.